![]() For the first time, a unique polymer of two types was isolated from samples of comfrey root cultures (the caffeic acid derivative is a new class of natural polyether with 3-(3,4-dihydroxyphenyl) glyceric acid as a repeating unit). In this study, the phenolic profile of extract samples of Symphytum officinale callus root cultures (up to 70% of ethanol) was determined using various approaches. Our findings demonstrated that extracts have significant antibacterial and anti-oxidant activities, attributed to their bioactive constituents.Ĭomfrey (Symphytum officinale) root preparations are known for their analgesic and anti-inflammatory properties. Despite the nanoparticles' appropriate particle size, the liposomal extract's antimicrobial effect was lower than that of the free form. The optimum formulation of liposomes contains the ratio of 75 mg lecithin, 25 mg cholesterol, and 50 mg herbal extract. A particle size analyzer detected the formulation size of 140 nm. The extracts' maximum inhibition zones against Staphylococcus epidermidis were established. Extracts of both plants showed antimicrobial activity. kurdicum had the highest anti-oxidant activity. n-butanol and ethyl acetate extracts of S. GC-MS analysis indicated that hexafarnesyl acetone was a major essential oil component. ![]() The film hydration method was used to fabricate nanoparticles. The antioxidant and antibacterial properties, essential oil compositions, total phenol, and flavonoid contents of different fractions were determined by DPPH test, disk diffusion assay, gas chromatography-mass spectrometry, Folin-ciocalteu reagent, and colorimetric assay method, respectively. The current study's objectives were to obtain different extracts and essential oils of Symphytum kurdicum and Symphytum asperrimum and to determine the chemical composition, as well as to evaluate free radical scavenging activity (IC50) and minimum bactericidal concentration (MBC), and the effect of liposomal formulation on antimicrobial properties.Īir-dried powdered aerial parts of S.
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